The College of Glycation with Dr. Paul Reynolds

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—explains how fasting is one of the most powerful and underutilized tools for resetting the glycation burden your body carries. He breaks down how the standard modern eating pattern of frequent, carbohydrate-rich meals drives near-constant glucose and insulin elevations that accelerate the formation of advanced glycation end products (AGEs). These permanent molecular modifications stiffen tissues, trigger inflammation through the RAGE receptor, and fuel the chronic diseases we associate with aging. Dr. Reynolds shows why this damage isn’t inevitable and how fasting interrupts the cycle at its root.He details the profound metabolic shifts that occur when you stop eating insulin drops, the body flips the “metabolic switch” to fat-burning and ketone production, and autophagy—the cellular recycling program—ramps up to clear out damaged, glycated proteins. Drawing on key research, he covers practical approaches including time-restricted eating, early time-restricted feeding, alternate-day fasting, extended fasts, and fasting-mimicking diets. You’ll also learn why how you break a fast matter and how these strategies improve insulin sensitivity, reduce oxidative stress, and enhance metabolic flexibility—independent of weight loss. Whether you’re new to fasting or looking to deepen your practice, this episode delivers a clear, science-backed roadmap for using one of the body’s own repair mechanisms to fight glycation and support long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Your gums may be telling you something critical about your metabolic health. In this episode of the College of Glycation, Dr. Paul Reynolds explores the overlooked connection between gum disease, glycation, and systemic inflammation. He explains how Advanced Glycation End Products (AGEs) form and accumulate—and how periodontal disease doesn’t just result from metabolic dysfunction, but can actively drive it. From inflammatory signaling to insulin resistance, this episode reveals how the mouth plays a central role in whole-body health. If you’re interested in metabolism, aging, or the deeper biochemical drivers of chronic disease, this episode offers a powerful new perspective on why oral health is far more than cosmetic—it’s metabolic.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how advanced glycation end-products (AGEs) quietly disrupt the body’s hormonal systems. Moving beyond blood sugar alone, he explains how glycation damages key proteins involved in hormone production, transport, and signaling—affecting thyroid function, testosterone levels, insulin sensitivity, and fertility. Even when lab results appear normal, these molecular changes can impair how hormones actually function at the tissue level.Dr. Reynolds connects the chemistry of glycation to real-world conditions like hypothyroidism, PCOS, infertility, and metabolic dysfunction, while introducing the RAGE pathway as a major driver of chronic inflammation and hormonal imbalance. This episode offers a deeper framework for understanding the link between diet, metabolic health, and endocrine function—and what you can do to reduce glycation and protect long-term health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores a major blind spot in metabolic health: fructose. While most discussions around sugar focus on glucose and blood sugar levels, this episode reveals why fructose may be even more damaging. Dr. Reynolds explains how fructose is metabolized almost entirely in the liver, bypassing key regulatory systems and driving fat production, insulin resistance, and oxidative stress. More importantly, fructose is significantly more reactive in the glycation process—accelerating the formation of advanced glycation end-products (AGEs) that damage tissues and promote chronic disease.Building on foundational glycation science, this episode uncovers how fructose not only glycates proteins faster than glucose but also generates highly reactive compounds like methylglyoxal, amplifying cellular damage. Dr. Reynolds challenges common assumptions about “healthy” sugars found in fruit juice and natural sweeteners, offering a clearer understanding of how modern dietary patterns contribute to long-term metabolic dysfunction. Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds introduces the foundational science of glycation—one of the most important and underrecognized processes driving aging and chronic disease. He explains how glucose, while essential for energy, can also react with proteins in the body through a non-enzymatic process that gradually leads to the formation of advanced glycation end-products (AGEs). Using clear analogies and step-by-step explanations, Dr. Reynolds walks through how glycation begins, how it progresses, and why its effects accumulate silently over time in tissues like blood vessels, kidneys, nerves, and eyes. This episode also explores the real-world implications of glycation in modern health, highlighting how lifestyle factors—such as diet, cooking methods, physical inactivity, and chronically elevated blood sugar—accelerate the process beyond what the body can manage. Dr. Reynolds outlines the body’s natural defense systems and, more importantly, the practical steps individuals can take to reduce glycation burden, improve metabolic health, and slow the long-term trajectory of aging and disease.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores one of the most important questions in metabolic health: Is glycation reversible? While some damage—especially in long-lived tissues like collagen—can persist for decades, this episode reveals that the body is far from helpless. Dr. Reynolds breaks down the science of how glycation forms, why certain stages are more reversible than others, and the built-in systems your body uses to defend against and clear this damage.More importantly, he translates that science into practical strategies you can use right away. From improving blood sugar control and reducing dietary AGEs to leveraging fasting, exercise, and targeted supplementation, this episode reframes the goal—not as fully reversing damage, but as slowing its accumulation and changing your long-term health trajectory.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

In this episode of the College of Glycation, Dr. Paul Reynolds explores a growing concern among health-conscious individuals: whether even “healthy” foods may be contributing to glycation and long-term metabolic damage. Prompted by real audience questions, he unpacks the science of advanced glycation end products (AGEs) with a focus on those introduced through diet, revealing that the true driver of AGE content is often not the food itself—but how it’s prepared.Drawing on decades of research, Dr. Reynolds explains how cooking methods like roasting and grilling dramatically increase AGE formation compared to lower-temperature, moisture-rich methods like boiling or steaming. He also breaks down how the body absorbs, processes, and clears dietary AGEs, and why metabolic health plays a central role in determining overall AGE burden. The episode delivers practical, evidence-based strategies to reduce glycation exposure—offering clarity and control to anyone looking to support long-term health and reduce inflammation at the molecular level.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation—long understood as a driver of aging and metabolic disease—may also underlie a range of specialized health conditions that often go unexplained. Moving beyond theory, he connects the biochemical process of advanced glycation end product (AGE) formation to real-world issues like frozen shoulder, vertigo, and MTHFR-related metabolic dysfunction. By breaking down how glycation alters long-lived proteins such as collagen, myelin, and vascular tissues, Dr. Reynolds reveals how a single molecular process can manifest across joints, nerves, and the inner ear.Drawing on peer-reviewed research and clear physiological explanations, this episode reframes seemingly unrelated diagnoses through a unified metabolic lens. You’ll gain insight into how glycation and homocysteine-driven protein damage may work together to accelerate dysfunction, why these processes often go undetected in standard clinical testing, and what this means for long-term health. Whether you’re dealing with chronic joint pain, unexplained neurological symptoms, or genetic findings like MTHFR, this conversation offers a deeper understanding of the hidden biochemical patterns shaping your health.Paul’s favorite yerba mate: https://unicity.link/121f260bfe  Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds  For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds  Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb  Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—shifts from explaining the science of glycation to exploring practical strategies for fighting it. Glycation and the buildup of advanced glycation end products (AGEs) contribute to aging, inflammation, and many chronic diseases, but there are evidence-based ways to slow this process. Dr. Reynolds breaks down the research behind several powerful tools that may help reduce glycation damage and improve metabolic health.This episode highlights supplements and dietary strategies that target glycation at multiple stages, including L-carnosine, pyridoxamine, GlyNAC (glycine + NAC), beta-hydroxybutyrate (BHB), and the polyphenols found in yerba mate. Dr. Reynolds also discusses the potential role of allulose as a lower-glycation sugar alternative and explains why improving insulin sensitivity and reducing blood glucose are foundational for protecting long-term cellular health. If you’re interested in slowing the molecular processes that contribute to aging and chronic disease, this episode provides practical, science-backed insights you can start applying today.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhbPaul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

In this episode of the College of Glycation, Dr. Paul Reynolds examines one of the most debated questions in metabolic health: do ketogenic and carnivore diets worsen glycation—or help prevent it? Breaking down the biochemistry, he explains how glycation forms advanced glycation end products (AGEs) that drive inflammation, oxidative stress, and accelerated aging, and why chronically elevated blood glucose is the primary trigger behind this damage.Dr. Reynolds explores how carbohydrate restriction lowers HbA1c and reduces endogenous AGE formation, while addressing concerns about dietary AGEs from cooked meat and methylglyoxal production during ketosis. He also highlights the protective role of beta-hydroxybutyrate (BHB), the body’s glyoxalase detoxification system, and the often-overlooked impact of fructose in accelerating glycation. The result is a clear, evidence-based look at how ketogenic and carnivore diets intersect with metabolic chemistry—and what that means for long-term health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how glycation impacts one of the most metabolically sensitive systems in the body: the reproductive system. From PCOS and ovarian dysfunction to erectile dysfunction and impaired nitric oxide signaling, this episode connects advanced glycation end products (AGEs) to hormonal imbalance, vascular damage, and chronic inflammation. Dr. Reynolds also examines gestational diabetes, placental dysfunction, and the emerging science of transgenerational metabolic programming—revealing how a mother’s metabolic health may influence not only her child, but potentially future generations.Grounded in peer-reviewed research, this conversation makes a compelling case that fertility and sexual health are not isolated issues—they are reflections of metabolic integrity. If you care about hormones, pregnancy, longevity, or preventing chronic disease, this episode underscores a powerful principle: protecting your metabolism protects everything downstream.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology—dives into the integumentary system and explains why your skin is one of the most revealing indicators of metabolic health. Unlike internal organs you can’t see, the effects of glycation and chronic inflammation show up directly on your face, hands, and body. Dr. Reynolds breaks down how advanced glycation end products (AGEs) form when sugars bind to proteins, and why long-lived structural proteins like collagen and elastin are especially vulnerable to becoming stiff, cross-linked, and dysfunctional over time.This lecture connects the biochemistry of glycation to real-world outcomes like wrinkles, sagging, dull or yellowed skin tone, barrier breakdown, increased infection risk, and delayed wound healing—especially in diabetes. You’ll also learn why skin autofluorescence is emerging as a powerful marker of AGE burden, even in non-diabetics, and how daily lifestyle choices can reduce glycation load and protect skin integrity as you age.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how glycation quietly damages two of the body’s most delicate and essential systems: the eyes and the ears. While most people associate diabetes-related damage with the heart or kidneys, this lecture shows how advanced glycation end products (AGEs) progressively harm the retina, lens, and cochlea through microvascular breakdown, oxidative stress, inflammation, and mitochondrial dysfunction—often long before someone is formally diagnosed with diabetes.You’ll learn why sensory organs are uniquely vulnerable due to their extreme metabolic demand, fragile end-artery circulation, and limited regenerative capacity. From pericyte loss and blood-retinal barrier failure in diabetic retinopathy, to crystallin protein cross-linking in cataracts, to the underrecognized connection between rising A1c and hearing loss, this episode connects molecular biochemistry to real-world outcomes—and highlights why reducing glycation through metabolic health is one of the most powerful strategies for protecting vision and hearing over a lifetime.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how glycation and metabolic dysfunction silently damage the nervous system. From neurons and myelin to the blood-brain barrier, Dr. Reynolds explains how advanced glycation end products (AGEs) disrupt electrical signaling, trigger inflammation through the AGE–RAGE pathway, impair mitochondrial function, and accelerate both peripheral neuropathy and cognitive decline. The nervous system’s high energy demands, limited antioxidant defenses, and irreplaceable neurons make it uniquely vulnerable to sugar-driven damage.Drawing from decades of peer-reviewed research, this episode connects metabolic health to brain aging, nerve degeneration, and even the emerging concept of Alzheimer’s disease as a form of metabolic dysfunction. Importantly, Dr. Reynolds emphasizes that these processes are not limited to people with diabetes—anyone with insulin resistance or high dietary AGE intake may be affected. This conversation offers a clear, science-based framework for understanding how diet, lifestyle, and glycation shape long-term neurological health—and what can be done to protect it.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds, Professor of Cell Biology and Physiology, explores how glycation and chronic inflammation undermine the musculoskeletal system—one of the body’s most critical drivers of movement, strength, and metabolic health. Beginning with normal muscle and bone physiology, Dr. Reynolds explains why skeletal muscle serves as the body’s primary glucose sink and how impaired glucose handling accelerates glycation, insulin resistance, mitochondrial dysfunction, and age-related muscle loss.The episode also examines bone and connective tissues, highlighting how glycation of long-lived collagen degrades tissue quality rather than density, increasing fracture risk, joint degeneration, and tendon injury—especially in diabetes and aging. Drawing from mechanistic and clinical research, Dr. Reynolds reveals how AGE accumulation, oxidative stress, and inflammation create reinforcing cycles that drive sarcopenia, frailty, osteoarthritis, and metabolic decline. The discussion closes by emphasizing why exercise—particularly resistance training—is one of the most powerful tools for countering glycation, preserving musculoskeletal integrity, and maintaining long-term metabolic resilience.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives into the kidneys, organs that quietly perform some of the most demanding work in the body. He begins by explaining how healthy kidneys filter massive volumes of blood, maintain fluid and electrolyte balance, regulate blood pressure, and preserve essential proteins through the highly specialized structure of the nephron. With nearly a million nephrons per kidney and an intricate filtration barrier built on size and charge selectivity, the kidneys are marvels of biological engineering—but also uniquely vulnerable to metabolic stress.Dr. Reynolds then reveals how glycation and chronic hyperglycemia progressively damage this delicate system. Advanced glycation end products (AGEs) alter long-lived structural proteins in the glomerular basement membrane, injure podocytes with limited regenerative capacity, and trigger inflammation and fibrosis through the AGE–RAGE axis. These processes drive hyperfiltration, albumin leakage, oxidative stress, and the vicious cycles that characterize diabetic kidney disease. The episode highlights why kidney damage is often silent until advanced stages, why early detection is critical, and how understanding these mechanisms provides a framework for preventing chronic kidney failure.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the liver’s central role in metabolic health and reveals how glycation and chronic inflammation quietly disrupt its vital functions. As the body’s primary metabolic hub, the liver is uniquely exposed to high concentrations of glucose and fructose, making it especially vulnerable to the formation of advanced glycation end products (AGEs). Dr. Reynolds breaks down how glycation alters liver enzymes, impairs insulin signaling, and initiates inflammatory cascades that ripple throughout the body.You’ll learn why fructose metabolism in the liver accelerates glycation through potent intermediates like methylglyoxal, how AGE–RAGE signaling drives fatty liver disease, fibrosis, and insulin resistance, and why the liver is both a victim and a driver of metabolic dysfunction. Grounded in peer-reviewed science, this episode provides a clear mechanistic framework for understanding fatty liver disease, diabetes, and systemic inflammation—and highlights why restoring liver health is one of the most powerful strategies for reclaiming metabolic resilience and long-term health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the blood and immune system to reveal how glycation and chronic hyperglycemia disrupt immunity, oxygen delivery, and inflammation control. Moving beyond the idea of blood sugar as a passive biomarker, Dr. Reynolds explains how glycation actively alters hemoglobin, stiffens red blood cells, and accelerates cellular aging, while simultaneously impairing the metabolic flexibility of immune cells. The result is a paradoxical state of chronic inflammation paired with weakened defense against infection.Drawing on peer-reviewed research, this episode connects metabolic dysfunction to real-world disease outcomes, including increased infection risk, atherosclerosis, kidney disease, and impaired wound healing. By unpacking how AGEs, immune cell metabolism, and inflammatory signaling intersect, Dr. Reynolds shows why metabolic health is foundational to immune resilience and healthy aging—and why reducing glycation isn’t just about improving lab numbers, but restoring the body’s capacity to defend, repair, and heal.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation podcast, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives into the science of glycation and its powerful role in accelerating skin aging. Glycation occurs when sugar molecules bind to proteins and fats, forming advanced glycation end products (AGEs) that damage collagen and elastin. Through AGE crosslinking, inflammatory signaling via the RAGE receptor, and increased oxidative stress, glycation quietly stiffens the skin and reduces elasticity, leading to wrinkles, sagging, and premature aging that originates at the cellular level.Dr. Reynolds connects molecular biochemistry with everyday lifestyle choices, explaining how diet, cooking methods, UV exposure, smoking, and metabolic health influence AGE accumulation in the skin. Drawing from peer-reviewed research, he outlines practical, evidence-based strategies—ranging from nutrition and antioxidants to UV protection and metabolic control—that can help slow or counteract glycation-related damage. This episode offers a clear, science-backed framework for understanding how metabolic health shows up on your skin and how targeted lifestyle interventions can support long-term skin resilience and healthy aging.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—kicks off a new physiology-focused series by exploring how glycation disrupts the metabolic and endocrine systems at the foundation of human health. Beginning with core concepts like insulin and glucagon signaling, fed versus fasted metabolism, and energy partitioning across liver, muscle, and adipose tissue, Dr. Reynolds builds a clear framework for understanding how the body normally regulates blood sugar and energy balance.From there, he reveals how non-enzymatic glycation and the accumulation of advanced glycation end products (AGEs) derail these systems through insulin resistance, chronic inflammation, and oxidative stress. By connecting molecular biochemistry to real-world conditions such as metabolic syndrome and type 2 diabetes, this episode shows why glycation is not just a complication of disease—but a driving force behind it. Whether you’re interested in physiology, metabolic health, or long-term disease prevention, this conversation lays the groundwork for understanding how sugar damage silently reshapes the body from the inside out.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Glycation doesn’t just alter blood sugar markers—it reshapes the kidneys in ways that silently drive disease. In this episode of the College of Glycation, Dr. Paul Reynolds breaks down how advanced glycation end products (AGEs) accumulate in renal tissues, stiffen filtering membranes, damage podocytes, and trigger the inflammatory RAGE pathway that accelerates diabetic nephropathy. Drawing from decades of biochemical and clinical research, Dr. Reynolds explains why the kidneys are uniquely vulnerable to elevated glucose, how glycation ignites oxidative stress and vascular dysfunction, and why early changes like microalbuminuria signal deeper metabolic trouble ahead.You’ll also learn how diet, cooking methods, exercise, and blood sugar control influence AGE formation—and what emerging therapies may help slow or reverse this trajectory. Whether you’re navigating diabetes, protecting your long-term renal health, or simply understanding how metabolic processes shape chronic disease, this episode offers actionable insights grounded in clear, rigorous science. Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how yerba mate—a traditional South American infusion rich in polyphenols, xanthines, and antioxidants—may offer powerful support against glycation and its wide-ranging metabolic consequences. By breaking down the science of AGEs, oxidative stress, and glucose dysregulation, Dr. Reynolds shows how yerba mate’s bioactive compounds can help stabilize blood sugar, reduce inflammation, enhance mitochondrial function, and even boost GLP-1 through microbiome-derived metabolites. It’s a deep dive into how a centuries-old herbal drink intersects with modern biochemistry to promote healthier aging and metabolic resilience. Drawing on peer-reviewed research and findings from his own lab, Dr. Reynolds explains the mechanisms behind yerba mate’s antioxidant capacity, carbonyl trapping, incretin effects, and tissue-specific metabolic benefits. Whether you're interested in functional nutrition, metabolic health, or practical strategies to reduce glycation, this episode reveals why yerba mate may be a valuable addition to a low-AGE, anti-inflammatory lifestyle.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds unpacks the powerful relationship between ketones and glycation, revealing how the body’s natural fat-derived fuel source can counteract one of the most damaging biochemical processes in modern health. He breaks down how glycation and advanced glycation end-products (AGEs) drive inflammation, oxidative stress, insulin resistance, and accelerated aging—and then shows how ketones, especially beta-hydroxybutyrate (BHB), interrupt this cycle by lowering glucose exposure, stabilizing insulin, enhancing mitochondrial efficiency, and suppressing inflammatory pathways like the NLRP3 inflammasome.Drawing from leading research and his own laboratory findings, Dr. Reynolds explains how ketosis reduces HbA1c, protects tissues from oxidative damage, and improves metabolic flexibility—while sharing practical tools listeners can use immediately, including low-AGE cooking strategies, fasting, exercise, and targeted exogenous ketones. Whether you're looking to reverse insulin resistance, slow down the biochemical aging process, or simply optimize metabolic health, this episode offers a clear, science-backed roadmap for using ketones to protect and repair the body at the cellular level.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this compelling episode of the College of Glycation podcast, Dr. Paul Reynolds unpacks the overlooked but powerful link between glycation—the sugar-driven chemical reaction happening inside all of us—and the development of cancer. Building on our ongoing exploration of AGEs, oxidative stress, and metabolic dysfunction, Dr. Reynolds explains how chronically elevated blood sugar and the accumulation of advanced glycation end-products ignite inflammation, damage DNA, disrupt cellular signaling, and ultimately create conditions where cancer can thrive. From the AGE–RAGE pathway to insulin resistance and metabolic syndrome, he breaks down the biochemical cascade that turns everyday dietary sugars into silent contributors to tumor growth.Drawing from cutting-edge research on breast, colorectal, and liver cancers, Dr. Reynolds highlights the growing evidence that dietary AGEs and modern food preparation methods are shaping cancer risk worldwide. He also offers practical strategies to lower AGE exposure, improve metabolic health, and reduce inflammation through nutrition, lifestyle, and smarter cooking techniques. Whether you're passionate about preventative health or simply curious about how metabolism influences disease, this episode delivers an eye-opening look at how sugar affects far more than just our waistlines—and what you can do to protect yourself.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives into the cutting-edge science behind detecting advanced glycation end products (AGEs) in our food. Building on years of research and a landmark 2025 Molecules review by Hiroyuki Kataoka, Dr. Reynolds unpacks how scientists measure these sugar-protein compounds that quietly influence everything from aging and inflammation to diabetes and cardiovascular health.From the chemistry of the Maillard reaction to the latest breakthroughs in chromatography and mass spectrometry, this lecture bridges the lab and the kitchen—showing how what happens in your frying pan connects to what happens in your cells. Learn how cooking methods, food choices, and antioxidants can help minimize dietary AGEs and support long-term metabolic resilience.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how glycation quietly undermines muscle strength, recovery, and performance. By binding sugars to proteins in the body, glycation produces toxic compounds known as AGEs that stiffen muscle fibers, disrupt collagen, and trigger chronic inflammation. The result? Slower recovery, greater injury risk, and accelerated muscle aging—even in those who train regularly.Dr. Reynolds connects cutting-edge biochemistry with everyday fitness, showing how high-sugar diets, poor recovery habits, and metabolic stress blunt the benefits of exercise. Backed by peer-reviewed research, he explores how glycation impairs flexibility, vascular health, and muscle regeneration—and shares practical strategies to reverse the damage. From anti-glycation nutrients like carnosine to smarter training and nutrition choices, this episode offers evidence-based tools to protect your muscles, optimize performance, and extend your athletic longevity.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores how toxic advanced glycation end-products (TAGEs) compromise gut integrity at the cellular level. Drawing on new research from Takeda et al. (2025), Dr. Reynolds explains how these sugar-derived toxins disrupt tight junction proteins like ZO-1 and claudin-7, leading to increased intestinal permeability, oxidative stress, and inflammation. The result? A weakened gut barrier that fuels chronic disease, from diabetes to neuroinflammation.Through clear scientific storytelling, Dr. Reynolds connects molecular biochemistry to real-world health—showing how diet, glucose overload, and oxidative stress silently erode intestinal resilience. He also highlights emerging strategies to protect the gut, including antioxidant defense, AGE inhibitors like aminoguanidine, and lifestyle approaches that preserve the body’s most important barrier.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—dives into how sugar-driven molecular damage accelerates skin aging from the inside out. Through the lens of glycation, he explains how advanced glycation end products (AGEs) stiffen collagen and elastin, weaken skin structure, and ignite inflammation through the RAGE pathway. The result? Wrinkles, sagging, and a loss of that youthful bounce—driven not just by time, but by diet, UV exposure, and everyday lifestyle choices.Blending cutting-edge research with practical takeaways, Dr. Reynolds reveals how diet, antioxidants, and AGE-lowering strategies can protect your skin’s integrity and slow the clock on aging. Whether you’re into skincare, nutrition, or metabolic health, this episode illuminates the powerful connection between what’s on your plate and what shows in the mirror—and offers science-backed tools to help your skin stay resilient, radiant, and strong.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this thought-provoking episode of the College of Glycation podcast, Dr. Paul Reynolds unpacks the powerful and overlooked connection between glycation and mental health. He explores how sugar-driven molecular damage—through advanced glycation end products (AGEs)—can inflame the brain, disrupt neurotransmitters like serotonin and dopamine, and worsen conditions such as depression, anxiety, and cognitive decline. By activating the RAGE pathway and impairing insulin signaling, glycation may serve as a biochemical bridge between metabolic dysfunction and psychiatric illness.Dr. Reynolds also highlights how diet, gut health, and lifestyle choices shape this relationship, offering practical ways to reduce glycation and protect brain function. Drawing on cutting-edge research in metabolic psychiatry, he reveals how improving insulin sensitivity, supporting gut integrity, and lowering AGE burden may hold the key to restoring emotional resilience and mental clarity.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this insightful episode of The College of Glycation, Dr. Paul Reynolds unpacks how sugar-driven molecular reactions silently erode your strength from the inside out. Glycation—the formation of advanced glycation end products (AGEs)—crosslinks muscle proteins, stiffens connective tissue, and disrupts insulin signaling, accelerating the loss of muscle mass and power known as sarcopenia.Drawing from current metabolic and clinical research, Dr. Reynolds explains how AGEs impair muscle regeneration, blunt key growth pathways like Akt/mTOR, and fuel inflammation that blocks repair. But it’s not all decline—he outlines practical, science-based strategies to restore resilience through resistance training, nutrient timing, and antioxidant support. Whether you’re aging, active, or simply determined to stay strong, this episode reveals how managing glycation can help preserve your mobility, vitality, and metabolic health for life.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds uncovers how glycation—the sugar-driven process behind advanced glycation end products (AGEs)—silently damages the lungs. From stiffened collagen and reduced elasticity to chronic inflammation fueled by RAGE signaling, glycation plays a hidden but powerful role in conditions like COPD, asthma, pulmonary fibrosis, and even lingering post-COVID complications.Blending research insights with practical strategies, Dr. Reynolds explores how both internal AGEs from high blood sugar and external ones from cigarette smoke or pollution converge to undermine respiratory health. Listeners will learn how diet, antioxidants, exercise, stress management, and breathing therapies can help preserve lung function, restore resilience, and slow glycation-related decline.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how sugar’s toxic fingerprints reshape the liver and fuel a silent epidemic: non-alcoholic fatty liver disease (NAFLD) and its aggressive cousin, NASH. Glycation and its byproducts, known as AGEs, act like molecular graffiti—damaging proteins, inflaming tissues, and driving fibrosis that can progress to cirrhosis and liver failure.Drawing on decades of research, Dr. Reynolds unpacks the biochemical chain reaction behind liver disease, from insulin resistance and de novo lipogenesis to RAGE signaling and stellate cell activation. Most importantly, he highlights evidence-based strategies—low-carb diets, intermittent fasting, exercise, and stress reduction—that can halt or even reverse early damage. Whether you’re concerned about metabolic health or simply want to protect your liver, this lecture offers practical tools and empowering science to take control.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals the overlooked but critical connection between glycation and sleep. Far from being a passive state, sleep is when the brain and body perform vital repair work, yet advanced glycation end products (AGEs) can sabotage this process. From disrupting melatonin production and circadian rhythms to worsening conditions like sleep apnea, insomnia, and restless leg syndrome, glycation quietly undermines our most restorative rhythms.Drawing on cutting-edge research, Dr. Reynolds explains how poor sleep, insulin resistance, and glycation form a destructive cycle—and, most importantly, how diet, exercise, stress management, and sleep hygiene can help break it. If you’ve ever struggled with sleep quality or want to protect long-term health, this episode offers both the science and the practical steps you need.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—reveals how glycation, the sugar-driven process that creates AGEs (advanced glycation end products), undermines human fertility. From sperm DNA damage and declining egg quality to impaired endometrial receptivity and placental dysfunction, glycation silently sabotages reproduction in both men and women. Linked to PCOS, endometriosis, male infertility, and gestational diabetes, this biochemical “rust” is emerging as a hidden driver of today’s fertility crisis.Drawing on peer-reviewed studies and clinical insights, Dr. Reynolds explains how AGEs alter reproductive biology—and, most importantly, what can be done about it. Listeners will learn actionable strategies to reduce AGE burden through diet, lifestyle, and promising new therapies. Whether you’re navigating fertility challenges, pregnancy complications, or simply seeking to better understand reproductive health, this episode offers a clear, science-backed roadmap for protecting the next generation.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation series, Dr. Paul Reynolds explores how sugar-driven damage in the form of advanced glycation end products (AGEs) accelerates brain aging and contributes to Alzheimer’s, Parkinson’s, depression, and other mental health challenges. He breaks down the science of glycation and insulin resistance, showing how they disrupt brain function, fuel inflammation, and create what many researchers call “Type 3 Diabetes.”Drawing from cutting-edge research and clinical insights, Dr. Reynolds highlights why standard treatments often fall short and how nutrition—particularly ketogenic therapies and low-AGE diets—can protect and even restore brain health. Packed with practical strategies and science-backed guidance, this conversation equips listeners with the tools to reduce glycation, support cognitive performance, and take control of long-term brain health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—explores the surprising biochemical connection between glycation and Polymyalgia Rheumatica (PMR), a painful inflammatory disorder that limits movement and quality of life. He explains how advanced glycation end-products (AGEs) can stiffen collagen, alter fascia, and transform the interstitial fluid that should keep muscles and joints moving freely—creating the perfect environment for pain and rigidity.Drawing on recent studies, Dr. Reynolds reveals how diet, inflammation, and oxidative stress intertwine in PMR, and why reducing sugar intake may help break the cycle. He also discusses ketogenic and low-carb eating as potential tools to lower AGE burden and ease stiffness, offering practical steps for protecting connective tissue health at any age.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this eye-opening episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—unpacks the hidden connection between glycation, mitochondrial damage, and declining cellular energy. He explains how sugar-driven advanced glycation end products (AGEs) sabotage the mitochondria—the body’s energy factories—by damaging key proteins, increasing oxidative stress, and choking off ATP production. The result? Fatigue, brain fog, metabolic inflexibility, and accelerated aging.Blending cutting-edge research with practical strategies, Dr. Reynolds reveals how to protect and restore your mitochondria through blood sugar control, targeted nutrition, and exercise that sparks mitochondrial renewal. Whether you’re aiming for sharper thinking, higher energy, or healthier aging, this episode offers the science and solutions to keep your cellular engines running strong.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation podcast, Dr. Paul Reynolds—Professor of Cell Biology and Biomedical Scientist—uncovers how a single biochemical process, glycation, can set off a chain reaction leading to metabolic syndrome. From stiffened arteries and distorted cholesterol to insulin resistance and mitochondrial damage, advanced glycation end-products (AGEs) quietly but powerfully drive the cluster of conditions that raise the risk of heart disease, stroke, and type 2 diabetes.Drawing on decades of research, Dr. Reynolds explains how AGEs form both inside the body and on our plates, thanks to high-heat cooking, processed foods, and sugar-heavy diets. You’ll learn how these “molecular wrecking balls” fuel inflammation, oxidative stress, and hormonal imbalance—and more importantly, how to interrupt the cycle. Packed with practical tips, this episode empowers you to make small, science-backed changes in your diet, lifestyle, and cooking habits to protect your metabolic health and longevity.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds, Professor of Cell Biology and Physiology, dives into the powerful yet underrecognized link between glycation and immune dysfunction. Learn how advanced glycation end products (AGEs) sabotage immune defenses by impairing macrophages, weakening antibodies, and triggering chronic inflammation through the AGE-RAGE pathway. Dr. Reynolds unpacks how these sugar-related changes contribute to aging, insulin resistance, and increased risk of infection, autoimmunity, and chronic disease.Backed by cutting-edge research, this lecture also offers practical strategies to protect and restore immune health—through smart dietary choices, physical activity, and antioxidant support. Whether you're a clinician, researcher, or health-conscious listener, this episode arms you with the knowledge to fight back against glycation and strengthen your body’s first line of defense.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds uncovers how sugar chemistry may be quietly compromising your vision. From cataracts and macular degeneration to diabetic retinopathy and glaucoma, glycation and its toxic byproducts—advanced glycation end products (AGEs)—wreak havoc on the delicate structures of the eye. With clarity and depth, Dr. Reynolds explains how long-lived eye proteins, oxidative stress, and insulin resistance create a perfect storm for vision loss.Drawing on recent research and clinical insights, he outlines practical strategies to slow glycation, improve metabolic health, and protect your sight through diet, antioxidants, and lifestyle change. Whether you're managing blood sugar, concerned about aging eyes, or simply want to stay ahead of chronic disease, this episode offers science-backed tools to keep your vision clear and strong.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds explores a surprising connection between sugar chemistry and your allergies. Building on previous discussions about glycation’s role in chronic disease, he dives into how advanced glycation end products (AGEs) can damage epithelial barriers, activate inflammatory pathways, and turbocharge allergic responses—from seasonal sneezing to asthma flare-ups.Dr. Reynolds also connects the dots between insulin resistance, processed foods, and immune overactivation, revealing how metabolic dysfunction may be silently amplifying your symptoms. Backed by peer-reviewed science and practical strategies, this episode offers a fresh perspective on why your allergies may be worse than they should be—and what you can do about it.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds explores the hidden impact of glycation on bone health—revealing how sugar-driven molecular damage weakens the very foundation of our bodies. Building on previous episodes, Dr. Reynolds explains how advanced glycation end products (AGEs) stiffen collagen, disrupt bone remodeling, and accelerate the progression of osteoporosis and osteoarthritis. Aging and insulin resistance further amplify this damage, making bones more fragile and susceptible to fractures—even when density appears normal.Drawing from cutting-edge research and real clinical insight, Dr. Reynolds breaks down the science behind progressive matrix loss, bone cell dysfunction, and the metabolic factors that erode skeletal strength over time. This episode isn’t just informative—it’s empowering. You’ll come away with practical, evidence-based strategies to lower AGE formation, improve insulin sensitivity, and preserve bone integrity for the long haul.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

Could sugar damage be silently fueling cancer? In this powerful episode of The College of Glycation, Dr. Paul Reynolds unpacks how a little-known process called glycation might be creating the perfect storm for tumors to grow and spread.You’ll learn how high blood sugar and insulin resistance do more than affect diabetes—they can generate toxic molecules called AGEs (advanced glycation end products) that inflame tissues, damage DNA, and create a cancer-friendly environment. Dr. Reynolds breaks down the science in clear, relatable terms and offers practical tips to protect yourself through diet, lifestyle, and smarter blood sugar control.If you're interested in preventing cancer, aging well, or just understanding what’s really happening in your body, this episode is a must-listen.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds dives into the often-overlooked link between sugar damage and gut health. Glycation—through its toxic byproducts known as AGEs—doesn’t just age your arteries or brain; it also wreaks havoc on your digestive system. Dr. Reynolds unpacks how AGEs contribute to leaky gut, microbiome imbalance, and inflammatory bowel conditions like IBD, while also fueling insulin resistance and systemic inflammation.Backed by cutting-edge research and clear clinical insights, this episode breaks down the molecular mayhem AGEs cause in the gut and offers practical, science-backed solutions—from dietary changes and prebiotics to blood sugar control and antioxidant support. Whether you're navigating digestive issues or simply want to protect your long-term metabolic health, this episode is a must-listen.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this powerful episode of the College of Glycation podcast, Dr. Paul Reynolds takes listeners deep into the hidden world of glycation and its devastating impact on kidney health. Building on previous episodes, Dr. Reynolds explains how advanced glycation end products (AGEs) silently damage the kidneys—compromising filtration, triggering chronic inflammation, and accelerating the march toward chronic kidney disease and dialysis. With clarity and urgency, he exposes how insulin resistance and elevated blood sugar fuel this process, creating a vicious metabolic cycle that threatens millions worldwide.Grounded in peer-reviewed science and rich historical context, this episode also explores emerging diagnostic tools like skin autofluorescence and highlights practical strategies to reduce AGE burden through diet, cooking methods, and lifestyle changes. Whether you're navigating diabetes or simply aiming to protect your long-term kidney function, this episode is a must-listen for anyone seeking to understand and interrupt the silent sabotage of glycation.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of the College of Glycation, Dr. Paul Reynolds explores how your everyday food choices contribute to the formation of harmful molecules called advanced glycation end products (AGEs). From grilling and frying to processed snacks and sugary drinks, modern diets are fueling inflammation, oxidative stress, and chronic disease through both endogenous and exogenous glycation pathways.Dr. Reynolds breaks down the science behind dietary glycation in clear terms and offers practical, evidence-based strategies to reduce your AGE exposure. Whether you're aiming to slow aging, manage blood sugar, or improve overall wellness, this episode gives you the tools to make smarter choices in the kitchen and protect your long-term health.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds turns the spotlight on the destructive interplay between glycation and diabetes, revealing how advanced glycation end products (AGEs) accelerate complications like neuropathy, retinopathy, and nephropathy. He explains how elevated blood sugar levels fuel AGE formation, setting off a chain reaction of tissue damage, inflammation, and oxidative stress—especially when insulin resistance is already in play. Backed by clinical studies and decades of metabolic research, Dr. Reynolds unpacks the biochemical feedback loop that makes glycation both a cause and consequence of worsening diabetes.Listeners will come away with a powerful understanding of why glycation is more than a side effect—it's a core driver of diabetic complications. From the AGE-RAGE signaling pathway to tools like skin autofluorescence and strategies to lower dietary AGE intake, this episode equips you with practical science to fight back. Whether you're navigating type 1 or type 2 diabetes, or seeking to prevent long-term damage, Dr. Reynolds delivers compelling, evidence-based insights to help break the cycle of sugar-driven disease.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this eye-opening episode of the College of Glycation, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—takes a deep dive into how advanced glycation end products (AGEs) silently sabotage your skin and connective tissues as you age. Building on the fundamentals of glycation, Dr. Reynolds explains how sugar molecules bind to collagen and elastin, locking them into stiff, unrepairable structures that lead to wrinkles, sagging, and visible signs of aging. But the damage doesn’t stop there—AGEs trigger inflammation, oxidative stress, and impair cellular repair mechanisms, making skin not only look older but function poorly, too.Dr. Reynolds goes beyond the surface to explore how glycation reflects a deeper metabolic crisis fueled by insulin resistance. Using compelling research and clinical insights, he connects aging skin to systemic issues in blood vessels, nerves, and organs—reminding us that our skin is a mirror of internal health. From the historical roots of glycation science to modern-day tools like skin autofluorescence, this episode is packed with actionable strategies to reduce AGE burden, improve skin health, and slow the biochemical processes of aging.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

In this episode of The College of Glycation, Dr. Paul Reynolds explores the damaging impact of glycation and advanced glycation end products (AGEs) on cardiovascular health. He explains how these sugar-derived molecules stiffen arteries, trigger inflammation, and contribute to conditions like hypertension, atherosclerosis, stroke, and heart failure. Backed by decades of peer-reviewed research, Dr. Reynolds walks listeners through how AGEs disrupt vascular function and why insulin resistance acts as a critical accelerator of this molecular damage.Listeners will gain a clear understanding of how glycation contributes to heart disease—even in those without diabetes—and discover practical strategies to reduce AGE burden through diet and lifestyle. Whether you're looking to protect your heart, manage blood sugar, or understand the deeper links between metabolism and chronic illness, this episode delivers evidence-based insights with clarity and urgency.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products) 

What if the foods we eat are quietly sabotaging our brain health? In this episode of The College of Glycation, Professor Paul Reynolds takes us deep into the science of glycation and its overlooked role in cognitive decline. From Alzheimer’s and Parkinson’s to anxiety and depression, we explore how sugar-damaged proteins—known as AGEs—wreak havoc on the brain’s delicate chemistry.You’ll hear the latest research on how high-AGE diets, insulin resistance, and inflammation converge to accelerate aging in the brain, and why conventional medications may not be enough. But it’s not all bad news—there’s promising evidence that dietary changes, including ketogenic approaches, may offer a way forward.If you’re curious about the hidden links between metabolism and mental health, this episode connects the dots with clarity and depth—no hype, just real science and actionable insights.Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3  Paul’s favorite source for clean, earth-sourced essentials such as salt, elecrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.  Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)  Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)