All Episodes
This Week In Medicine — 240 episodes
JAMA 9 2026 Low-Voltage Ablation in Persistent Atrial Fibrillation The IDEAL-AF Randomized Clinical Trial
JAMA 9 2026 Adoption of Adjunctive Azithromycin for Unscheduled Cesarean Delivery and Postpartum Infections
NEJM 9 10 2026 Complete Revascularization Guided by Functional Coronary Angiography in STEMI
NEJM 9 10 2026 Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy
NEJM 9 10 2026 Exa-cel in Children with Transfusion-Dependent β-Thalassemia or Sickle Cell Disease
Circulation 8 2026 Bempedoic Acid and First and Recurrent Limb Outcomes in Statin-Intolerant Patients With Peripheral Artery Disease
Circulation 8 2026 Semaglutide and the Inflammatory Pathways to Cardiovascular Health
JAMA August 2026 Methadone vs Buprenorphine-Naloxone in Opioid Overdose Survivors
JAMA August 2026 Arginine Therapy for Sickle Cell Disease Acute Pain Episodes
JAMA August 2026 Predictive Utility of Coronary Artery Calcium Score Added to the PREVENT Atherosclerotic Cardiovascular Disease Equations
NEJM 2026 Survodutide Once Weekly for the Treatment of Adults with Obesity
NEJM August 2026 Azithromycin for Preschoolers with Wheezing in the Emergency Department
NEJM August 2026 Carbocisteine or Hypertonic Saline for Acute Respiratory Failure
NEJM August 2026 Selpercatinib in Early-Stage RET Fusion–Positive Non–Small-Cell Lung Cancer
NEJM August 2026 In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia
NEJM August 2026 Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica
NEJM August 2026 Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease
NEJM August 2026 Perioperative Apalutamide in High-Risk Localized Prostate Cancer
NEJM August 2026 Finerenone in Persons with Chronic Kidney Disease without Diabetes
NEJM July 2026 Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain.
NEJM July 2026 PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer
NEJM July 2026 Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy.
NEJM July 2026 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus
NEJM July 2026 Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease
NEJM July 2026 Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma
BMJ July 2026 Robotic versus Open Pancreatoduodenectomy (PORTAL): multicentre, single masked, phase 3, non-inferiority randomised controlled trial
BMJ July 2026 Venous thromboembolism after mechanical restraint in psychiatric hospitals
BMJ July 2026 Comparative effects of drugs for adults with overweight or obesity
JAMA Internal Medicine July 2026 Respiratory Outbreak Mitigation With Point-of-Care Testing in Long-Term Care
JAMA Cardiology July 2026 Dual Antiplatelet Therapy Duration in Patients at High Bleeding Risk
JAMA Cardiology July 2026 Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
JAMA July 2026 Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure The RAFT Clinical Trial
JAMA July 2026 Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease
JAMA July 2026 Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer.
Lancet July 2026 Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Lancet July 2026 Mapping the prevalence of molecular markers of Plasmodium falciparum artemisinin partial resistance in Africa: a systematic review and spatiotemporal modelling study
Lancet July 2026 Neurodegenerative mortality among National Football League Players
NEJM June 2026 A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis
NEJM June 2028 Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery
NEJM June 2028 Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation
NEJM June 2028 Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection
JAMA June 2026 Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers Importance
JAMA June 2026 Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis The PARADIGM Randomized Clinical Trial.
JAMA June 2026 Self-Directed vs Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain A Randomized Clinical Trial.
NEJM June 2026 Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection.
May 2026 Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic Cance
NEJM May 2026 Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention
NEJM 4 2026 Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors.
NEJM 4 2026 A Multicomponent Intervention to Improve Maternal Infection Outcomes
NEJM April 2026 First-Line Zongertinib in Advanced HER2-Mutant Non–Small-Cell Lung Cancer
NEJM 4 23 2026 Transdermal Estradiol Patches in Locally Advanced Prostate Cancer.
NEJM 4 23 2206 Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients.
NEJM 4 23 2026: Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage
JAMA 4 2026 Cost-Effectiveness of ApoB, Non–HDL-C, and LDL-C Goals for Primary Prevention Lipid-Lowering Therapy.
JAMA 4 2026 Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy
JAMA 4 2026 Real-World Outcomes of Transcatheter Tricuspid Valve Replacement Analysis From the STS/ACC TVT Registry
NEJM 4 2026 Discontinuation of Beta-Blocker Therapy after Myocardial Infarction.
NEJM 4 2026 eft Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation
NEJM 4 2026 Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease
NEJM 4 2026 Multifaceted Strategies for Hypertension Control in Low-Income Patients
NEJM 4 2026 Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer
NEJM 3 26 26 Dengue Suppression by Male Wolbachia-Infected Mosquitoes.
NEJM 3 26 26 Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years
NEJM 3 26 26 Atezolizumab plus FOLFOX for Stage III Mismatch Repair–Deficient Colon Cancer
Lancet March 2026 Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study
Lancet March 2026 The effectiveness of HPV vaccination against invasive cervical cancer and related precancerous lesions: a multinational target trial emulation study
NEJM March 12 2026 Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia
NEJM March 12 2026 Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia
NEJM March 12 2026 Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism
JAMA Pediatrics March 2026 Screen Use at Bedtime and Sleep Duration and Quality Among Youths
NEJM March 5 2026 Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction
NEJM March 5 2026 Finerenone in Type 1 Diabetes and Chronic Kidney Disease
JAMA February 2026 Coffee and Tea Intake, Dementia Risk, and Cognitive Function
JAMA February 2026 Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation
JAMA February 2026 Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging
NEJM February 2026 Tecovirimat for the Treatment of Mpox
NEJM February 2026 Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges
NEJM February 2026 Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer
Lancet February 2026 Serotype-specific pneumococcal invasiveness: a global meta-analysis of paired estimates of disease incidence and carriage prevalence B
Lancet February 2026 End-to-end integrative segmentation and radiomics prognostic models for risk stratification of high-grade serous ovarian cancer: a retrospective multicohort study
Lancet February 2026 Zegocractin for acute pancreatitis with systemic inflammatory response syndrome: a randomized, controlled, dose-ranging, phase 2b trial
NEJM February 19 2026 An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1
NEJM February 19 2026 Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma
JAMA February 5 Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke
JAMA February 11 Coffee and Tea Intake, Dementia Risk, and Cognitive Function.
JAMA February 11 Emergency Department–Initiated Buprenorphine for Opioid Use Disorder
NEJM February 2026 Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents
NEJM February 2026 A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy
NEJM February 2026 Sibeprenlimab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial
Lancet February 2026 Smartwatch-derived versus self-reported outcomes of physiological recovery after COVID-19, influenza, and group A streptococcus: a 2-year prospective cohort study
Lancet February 2026, Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank
NEJM February 5,2026 Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer
NEJM February 5,2026 Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.
NEJM February 5,2026:A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide
American Journal of HTN January 2026 Trends in Initial Combination Antihypertensive Therapy in a US Health System
JAMA Network Open ID Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital
NEJM January 28, 2026: A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D
NEJM January 28,2026 Nivolumab for Resected Stage III or IV Melanoma at 9 Years
NEJM January 28,2026 Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation
NEJM January 22,2026 Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer
NEJM January 22,2026:Nivolumab for Resected Stage III or IV Melanoma at 9 Years
NEJM January 22,2026:Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation.
NEJM January 2026 Fremanezumab in Children and Adolescents with Episodic Migraine
NEJM January 2026 ORIGINAL ARTICLE Share on Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD
NEJM January 2026;Medical Management and Revascularization for Asymptomatic Carotid Stenosis
Lancet : January 2026 Mortality and long-term exposure to source-specific PM2·5: evidence from a national cohort study in China
Lancet : January 2026:SARS-CoV-2 infectious shedding and rebound among adults with and without oral antiviral use: two case-ascertained prospective household studies
Lancet : January 2026, REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial
NEJM January 8, 2026 RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults
NEJM January 8, 2026 Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis
NEJM January 8, 2026
Circulation:January 6, 2026:Circulation:January 6, 2026 Deep Learning–Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation
Circulation:January 6, 2026 Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial
Circulation:January 6, 2026 Cardiac Allograft Vasculopathy Inhibition With Alirocumab: The CAVIAR Trial
THE LANCET: December 31, 2025:International trends and social disparities in pain of adults aged 50 years and older in 22 countries across Europe, Asia, and the Americas: a longitudinal population-based study
THE LANCET Volume 407, Issue 10523P31-52January 03, 2026 Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
N Engl J Med 2026;394:51-61 Dual Targeting of Extramedullary Myeloma with Talquetamab and Teclistamab
NEJM: Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC
N Engl J Med 2026;394:13-26 Sacituzumab Tirumotecan in EGFR-TKI–Resistant, EGFR-Mutated Advanced NSCLC
Most Popular Articles JAMA 2025 Episode 2:Screening for Osteoporosis to Prevent Fractures US Preventive Services Task Force Recommendation Statement
Most Popular Articles JAMA 2025 Episode 1:The DECAF Trial
The Lancet December 2025:Neurobehavioural links from infant screen time to anxiety
Best of JAMA 2025: Episode 9:Nicotinamide for Skin Cancer Chemoprevention
Best of JAMA 2025: Episode 8:Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use
Best of JAMA 2025: Episode 7: Global Estimates of Lives and Life-Years Saved by COVID-19 Vaccination During 2020-2024
Best of JAMA 2025: Episode 6:Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related Macular Degeneration
Best of JAMA 2025: Episode 5:Outcomes of Solid Organ Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors A Systematic Review and Individual Participant Data Meta-Analysis
Best of JAMA 2025: Episode 4:Residual Risk of Recurrent Stroke Despite Anticoagulation in Patients With Atrial Fibrillation A Systematic Review and Meta-Analysis
Best of JAMA 2025: Episode 3:Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses
Best of JAMA 2025: Episode 2:Projected Lifetime Cancer Risks From Current Computed Tomography Imaging
Best of JAMA 2025: Episode 1: Proximity to Golf Courses and Risk of Parkinson Disease
Lancet:December 19, 2025: Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study
NATURE:Eleven clinical trials that will shape medicine in 2026
The LANCET:Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study Volume 406, Issue 10521P2757-2771December 13, 2025
Neurology: High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia Evidence From a 25-Year Prospective Cohort Study
JAMA December 2026 Valacyclovir Treatment of Early Symptomatic Alzheimer Disease The VALAD Randomized Clinical Trial
Annals of Internal Medicine December 2026 Eligibility and Prognostic Performance of Smoking Duration–Based Versus Pack-Year–Based U.S. National Lung Cancer Screening Criteria Across Racial and Ethnic Groups
NEJM December 2026 Part III
NEJM December 2026 Part II
NEJM December 11 2026
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