All Episodes

NEJM August 2026 Selpercatinib in Early-Stage RET Fusion–Positive Non–Small-Cell Lung Cancer

NEJM August 2026 In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia

NEJM August 2026 Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica

NEJM August 2026 Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease

NEJM August 2026 Perioperative Apalutamide in High-Risk Localized Prostate Cancer

NEJM August 2026 Finerenone in Persons with Chronic Kidney Disease without Diabetes

NEJM July 2026 Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain.

NEJM July 2026 PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer

NEJM July 2026 Teclistamab in Multiple Myeloma with One to Three Previous Lines of Therapy.

NEJM July 2026 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus

NEJM July 2026 Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease

NEJM July 2026 Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma

BMJ July 2026 Robotic versus Open Pancreatoduodenectomy (PORTAL): multicentre, single masked, phase 3, non-inferiority randomised controlled trial

BMJ July 2026 Venous thromboembolism after mechanical restraint in psychiatric hospitals

BMJ July 2026 Comparative effects of drugs for adults with overweight or obesity

JAMA Internal Medicine July 2026 Respiratory Outbreak Mitigation With Point-of-Care Testing in Long-Term Care

JAMA Cardiology July 2026 Dual Antiplatelet Therapy Duration in Patients at High Bleeding Risk

JAMA Cardiology July 2026 Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction

JAMA July 2026 Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure The RAFT Clinical Trial

JAMA July 2026 Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease

JAMA July 2026 Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer.

Lancet July 2026 Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.

Lancet July 2026 Mapping the prevalence of molecular markers of Plasmodium falciparum artemisinin partial resistance in Africa: a systematic review and spatiotemporal modelling study

Lancet July 2026 Neurodegenerative mortality among National Football League Players

NEJM June 2026 A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis

NEJM June 2028 Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery

NEJM June 2028 Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation

NEJM June 2028 Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection

JAMA June 2026 Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers Importance

JAMA June 2026 Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis The PARADIGM Randomized Clinical Trial.

JAMA June 2026 Self-Directed vs Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain A Randomized Clinical Trial.

NEJM June 2026 Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection.

May 2026 Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic Cance

NEJM May 2026 Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention

NEJM 4 2026 Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors.

NEJM 4 2026 A Multicomponent Intervention to Improve Maternal Infection Outcomes

NEJM April 2026 First-Line Zongertinib in Advanced HER2-Mutant Non–Small-Cell Lung Cancer

NEJM 4 23 2026 Transdermal Estradiol Patches in Locally Advanced Prostate Cancer.

NEJM 4 23 2206 Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients.

NEJM 4 23 2026: Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage

JAMA 4 2026 Cost-Effectiveness of ApoB, Non–HDL-C, and LDL-C Goals for Primary Prevention Lipid-Lowering Therapy.

JAMA 4 2026 Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

JAMA 4 2026 Real-World Outcomes of Transcatheter Tricuspid Valve Replacement Analysis From the STS/ACC TVT Registry

NEJM 4 2026 Discontinuation of Beta-Blocker Therapy after Myocardial Infarction.

NEJM 4 2026 eft Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation

NEJM 4 2026 Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease

NEJM 4 2026 Multifaceted Strategies for Hypertension Control in Low-Income Patients

NEJM 4 2026 Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer

NEJM 3 26 26 Dengue Suppression by Male Wolbachia-Infected Mosquitoes.

NEJM 3 26 26 Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years

NEJM 3 26 26 Atezolizumab plus FOLFOX for Stage III Mismatch Repair–Deficient Colon Cancer

Lancet March 2026 Epidemiology, ventilation, and outcomes of acute respiratory failure in immunocompromised patients from 103 intensive care units in 26 countries: a retrospective observational study

Lancet March 2026 The effectiveness of HPV vaccination against invasive cervical cancer and related precancerous lesions: a multinational target trial emulation study

NEJM March 12 2026 Fixed-Duration versus Continuous Treatment for Chronic Lymphocytic Leukemia

NEJM March 12 2026 Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia

NEJM March 12 2026 Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism

JAMA Pediatrics March 2026 Screen Use at Bedtime and Sleep Duration and Quality Among Youths

NEJM March 5 2026 Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction

NEJM March 5 2026 Finerenone in Type 1 Diabetes and Chronic Kidney Disease

JAMA February 2026 Coffee and Tea Intake, Dementia Risk, and Cognitive Function

JAMA February 2026 Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation

JAMA February 2026 Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging

NEJM February 2026 Tecovirimat for the Treatment of Mpox

NEJM February 2026 Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges

NEJM February 2026 Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer

Lancet February 2026 Serotype-specific pneumococcal invasiveness: a global meta-analysis of paired estimates of disease incidence and carriage prevalence B

Lancet February 2026 End-to-end integrative segmentation and radiomics prognostic models for risk stratification of high-grade serous ovarian cancer: a retrospective multicohort study

Lancet February 2026 Zegocractin for acute pancreatitis with systemic inflammatory response syndrome: a randomized, controlled, dose-ranging, phase 2b trial

NEJM February 19 2026 An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1

NEJM February 19 2026 Teclistamab plus Daratumumab in Relapsed or Refractory Multiple Myeloma

JAMA February 5 Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke

JAMA February 11 Coffee and Tea Intake, Dementia Risk, and Cognitive Function.

JAMA February 11 Emergency Department–Initiated Buprenorphine for Opioid Use Disorder

NEJM February 2026 Therapy for Atrial Fibrillation in Patients with Drug-Eluting Stents

NEJM February 2026 A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy

NEJM February 2026 Sibeprenlimab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial

Lancet February 2026 Smartwatch-derived versus self-reported outcomes of physiological recovery after COVID-19, influenza, and group A streptococcus: a 2-year prospective cohort study

Lancet February 2026, Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank

NEJM February 5,2026 Trastuzumab Deruxtecan plus Pertuzumab for HER2-Positive Metastatic Breast Cancer

NEJM February 5,2026 Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.

NEJM February 5,2026:A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide

American Journal of HTN January 2026 Trends in Initial Combination Antihypertensive Therapy in a US Health System

JAMA Network Open ID Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital

NEJM January 28, 2026: A Phase 2 Trial of Tobevibart plus Elebsiran in Hepatitis D

NEJM January 28,2026 Nivolumab for Resected Stage III or IV Melanoma at 9 Years

NEJM January 28,2026 Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation

NEJM January 22,2026 Sacituzumab Govitecan plus Pembrolizumab for Advanced Triple-Negative Breast Cancer

NEJM January 22,2026:Nivolumab for Resected Stage III or IV Melanoma at 9 Years

NEJM January 22,2026:Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation.

NEJM January 2026 Fremanezumab in Children and Adolescents with Episodic Migraine

NEJM January 2026 ORIGINAL ARTICLE Share on Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD

NEJM January 2026;Medical Management and Revascularization for Asymptomatic Carotid Stenosis

Lancet : January 2026 Mortality and long-term exposure to source-specific PM2·5: evidence from a national cohort study in China

Lancet : January 2026:SARS-CoV-2 infectious shedding and rebound among adults with and without oral antiviral use: two case-ascertained prospective household studies

Lancet : January 2026, REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial

NEJM January 8, 2026 RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults

NEJM January 8, 2026 Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis

NEJM January 8, 2026

Circulation:January 6, 2026:Circulation:January 6, 2026 Deep Learning–Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation

Circulation:January 6, 2026 Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial

Circulation:January 6, 2026 Cardiac Allograft Vasculopathy Inhibition With Alirocumab: The CAVIAR Trial

THE LANCET: December 31, 2025:International trends and social disparities in pain of adults aged 50 years and older in 22 countries across Europe, Asia, and the Americas: a longitudinal population-based study

THE LANCET Volume 407, Issue 10523P31-52January 03, 2026 Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

N Engl J Med 2026;394:51-61 Dual Targeting of Extramedullary Myeloma with Talquetamab and Teclistamab

NEJM: Survival with Osimertinib plus Chemotherapy in EGFR-Mutated Advanced NSCLC

N Engl J Med 2026;394:13-26 Sacituzumab Tirumotecan in EGFR-TKI–Resistant, EGFR-Mutated Advanced NSCLC

Most Popular Articles JAMA 2025 Episode 2:Screening for Osteoporosis to Prevent Fractures US Preventive Services Task Force Recommendation Statement

Most Popular Articles JAMA 2025 Episode 1:The DECAF Trial

The Lancet December 2025:Neurobehavioural links from infant screen time to anxiety

Best of JAMA 2025: Episode 9:Nicotinamide for Skin Cancer Chemoprevention

Best of JAMA 2025: Episode 8:Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use

Best of JAMA 2025: Episode 7: Global Estimates of Lives and Life-Years Saved by COVID-19 Vaccination During 2020-2024

Best of JAMA 2025: Episode 6:Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related Macular Degeneration

Best of JAMA 2025: Episode 5:Outcomes of Solid Organ Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors A Systematic Review and Individual Participant Data Meta-Analysis

Best of JAMA 2025: Episode 4:Residual Risk of Recurrent Stroke Despite Anticoagulation in Patients With Atrial Fibrillation A Systematic Review and Meta-Analysis

Best of JAMA 2025: Episode 3:Genetic Architecture and Risk of Childhood Maltreatment Across 5 Psychiatric Diagnoses

Best of JAMA 2025: Episode 2:Projected Lifetime Cancer Risks From Current Computed Tomography Imaging

Best of JAMA 2025: Episode 1: Proximity to Golf Courses and Risk of Parkinson Disease

Lancet:December 19, 2025: Persistence to antihypertensive drug classes in uncomplicated hypertension: a nationwide Swedish cohort study

NATURE:Eleven clinical trials that will shape medicine in 2026

The LANCET:Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study Volume 406, Issue 10521P2757-2771December 13, 2025

Neurology: High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia Evidence From a 25-Year Prospective Cohort Study

JAMA December 2026 Valacyclovir Treatment of Early Symptomatic Alzheimer Disease The VALAD Randomized Clinical Trial

Annals of Internal Medicine December 2026 Eligibility and Prognostic Performance of Smoking Duration–Based Versus Pack-Year–Based U.S. National Lung Cancer Screening Criteria Across Racial and Ethnic Groups

NEJM December 2026 Part III

NEJM December 2026 Part II

NEJM December 11 2026

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